Clinical Trials

Listed below are clinical trials being conducted by principal investigator, Puja Mehta, MD.  For more information on these studies or to refer a patient, please contact Senait Asier at senait.asier@emory.edu or 404-727-7513.

ISCHEMIA

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches

Sponsor: NIH: NHLBI

Purpose: The purpose of the ISCHEMIA trial is to determine the best management strategy for higher-risk patients with stable ischemic heart disease. This is a multicenter randomized controlled trial with a target enrollment of ~8000 patients with at least moderate ischemia on stress imaging. Patients will be assigned at random to a routine invasive strategy (INV) with cardiac catheterization (cath) followed by revascularization plus optimal medical therapy (OMT) or to a conservative strategy (CON) of OMT, with cath and revascularization reserved for those who fail OMT.

Inclusion Criteria:

  • At least moderate ischemia on a stress imaging test with nuclear myocardial perfusion (≥10% myocardium), echo or cardiac magnetic resonance wall motion (≥3/16 segments with stress-induced severe hypokinesis or akinesis), or cardiac magnetic resonance perfusion (≥12% myocardium).
  • Participant is willing to comply with all aspects of the protocol, including adherence to medical therapy and follow-up visits
  • Age > 21 years

See the patient brochure for more information.